Boc-N-Me-Val-Val CAS 863781-44-6 Boc Peptide Intermediate N-methyl Amino Acid Derivative

High-purity Boc-N-Me-Val-Val for peptide development.

Used as a key dipeptide building block in:

• Solution-phase peptide synthesis
• Solid-phase peptide synthesis (SPPS)
• Fragment condensation strategies

The pre-assembled Val-Val fragment helps:

• Improve coupling efficiency
• Reduce synthesis steps
• Minimize racemization
• Facilitate difficult sequence synthesis

The N-methyl amino acid motif is frequently introduced to:

• Improve protease resistance
• Enhance metabolic stability
• Reduce hydrogen bonding
• Modify peptide conformation
• Increase lipophilicity
• Improve membrane permeability

Therefore, Boc-N-Me-Val-Val is commonly used in:

• Therapeutic peptide optimization
• Peptidomimetic research
• Structure-activity relationship (SAR) studies

Widely applied in the synthesis of:

• Cyclic peptides
• Constrained peptides
• Lipopeptides
• Peptidomimetics
• Hydrophobic peptide fragments

The hydrophobic Val-Val sequence combined with N-methylation can help improve:

• Conformational stability
• Receptor affinity
• Pharmacokinetic properties

Frequently used in:

• Peptide drug discovery
• Oncology peptide research
• Metabolic disease peptide projects
• CNS peptide development
• Advanced peptide intermediate synthesis